BDBM50117271 1-(2,6-dimethylphenoxy)-2-propanolamine::1-(2,6-dimethylphenoxy)propan-2-amine::2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine::2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine(mexiletine)::CHEMBL558::MEXILETINE::Mexitil

SMILES CC(N)COc1c(C)cccc1C

InChI Key InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N

Data  2 KI  31 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50117271   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human recombinant Nav1.5 channel expressed in HEK293 cells by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  7.80E+3nMAssay Description:Inhibition of human NaV1.5 by IonWorks quattro automated electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  4.20E+5nMAssay Description:Blockade of human full-length NaV1.5 expressed in HEK293 cells co-transfected with pCD8-IRES-hbeta1 assessed as 0.1 Hz of half-maximal tonic-induced ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  5.80E+4nMAssay Description:Blockade of human full-length NaV1.5 expressed in HEK293 cells co-transfected with pCD8-IRES-hbeta1 assessed as 10 Hz of use-dependent-induced channe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin)-mediated late channel currentMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50117271(1-(2,6-dimethylphenoxy)-2-propanolamine | 1-(2,6-d...)
Affinity DataIC50:  1.50E+4nMAssay Description:Concentration at which the clotting time was prolonged by twice that of the control by inhibiting thrombinMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank